Charleston is where the Old South began and Henry Woodward, a humble ship's surgeon, would become its first settler. In a world full of masters and slaves, soldiers and pirates, Woodward struggles for survival on the American frontier with the help of Native allies. In 1665, the owners of Carolina, the Lords Proprietors, commission Sir John Yeamans as Governor. Yeamans sends Woodward on an expedition to found a colony at Port Royal, Carolina. In this serialized anthology the story of this city's rise and fall is told through the intertwining lives of its citizens, both famous and forgotten, starting with its founding resident, Dr. Henry Woodward.